Molecular basis of gating charge immobilization in Shaker potassium channels.

@article{Bezanilla1991MolecularBO,
  title={Molecular basis of gating charge immobilization in Shaker potassium channels.},
  author={Francisco Bezanilla and Eduardo Perozo and Diane M Papazian and Enrico Stefani},
  journal={Science},
  year={1991},
  volume={254 5032},
  pages={679-83}
}
Voltage-dependent ion channels respond to changes in the membrane potential by means of charged voltage sensors intrinsic to the channel protein. Changes in transmembrane potential cause movement of these charged residues, which results in conformational changes in the channel. Movements of the charged sensors can be detected as currents known as gating currents. Measurement of the gating currents of the Drosophila Shaker potassium channel indicates that the charge on the voltage sensor of the… CONTINUE READING

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