Molecular basis of feline beta-glucuronidase deficiency: an animal model of mucopolysaccharidosis VII.

@article{Fyfe1999MolecularBO,
  title={Molecular basis of feline beta-glucuronidase deficiency: an animal model of mucopolysaccharidosis VII.},
  author={John C. Fyfe and Rebeccah L. Kurzhals and M Lassaline and Paula S. Henthorn and Prasad Alur and Pingzhang Wang and J. H. Wolfe and Urs Giger and Mark E. Haskins and Donald Franklin Patterson and Huai-chang Sun and Samta Jain and Naoya Yuhki},
  journal={Genomics},
  year={1999},
  volume={58 2},
  pages={
          121-8
        }
}
A family of domestic cats was found that exhibited clinical and biochemical abnormalities consistent with mucopolysaccharidosis VII, an autosomal recessive lysosomal storage disorder caused by beta-glucuronidase deficiency. beta-Glucuronidase activity was undetectable in affected cat fibroblasts and restored by retroviral gene transfer of rat beta-glucuronidase cDNA. beta-Glucuronidase mRNA was normal in affected cat testis by Northern blot analysis. Normal feline beta-glucuronidase cDNA was… CONTINUE READING
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