Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2.

Abstract

Induction of drug-metabolizing enzymes through the antioxidant response element (ARE)-dependent transcription was initially implicated in chemoprevention against cancer by antioxidants. Recent progress in understanding the biology and mechanism of induction revealed a critical role of induction in cellular defense against electrophilic and oxidative stress… (More)
DOI: 10.1124/pr.110.004333

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@article{Ma2012MolecularBO, title={Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2.}, author={Qiang Ma and X. He}, journal={Pharmacological reviews}, year={2012}, volume={64 4}, pages={1055-81} }