Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus.

@article{Solomou2001MolecularBO,
  title={Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus.},
  author={Elena E. Solomou and Y T Juang and Mark F. Gourley and Gary M. Kammer and George C Tsokos},
  journal={Journal of immunology},
  year={2001},
  volume={166 6},
  pages={4216-22}
}
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterized by diverse cellular and biochemical aberrations, including decreased production of IL-2. Here we show that nuclear extracts from unstimulated SLE T cells, unlike extracts from normal T cells, express increased amounts of phosphorylated cAMP-responsive element modulator (p-CREM) that binds the -180 site of the IL-2 promoter. Nuclear extracts from stimulated normal T cells display increased binding of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Activator protein-1 (AP-1) regulation in lymphocytes from patients with systemic lupus erythematosus

H. K. Wong, G. M. Kammer, N. Mishra, G. Dennis, G. C. Tsokos
Arthritis Rheum. 42:S1446 • 1999
View 7 Excerpts
Highly Influenced

T lymphocytes, natural killer cells, cytokines, and immune regulation

D. A. Horwitz, W. Stohl, J. D. Gray
In Dubois’ Lupus Erythematosus, • 1997
View 4 Excerpts
Highly Influenced

Transcriptional regulation by cyclic AMP-responsive factors.

Progress in nucleic acid research and molecular biology • 2000
View 3 Excerpts

Similar Papers

Loading similar papers…