Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus.

  title={Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus.},
  author={Elena E. Solomou and Y T Juang and Mark F. Gourley and Gary M. Kammer and George C Tsokos},
  journal={Journal of immunology},
  volume={166 6},
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterized by diverse cellular and biochemical aberrations, including decreased production of IL-2. Here we show that nuclear extracts from unstimulated SLE T cells, unlike extracts from normal T cells, express increased amounts of phosphorylated cAMP-responsive element modulator (p-CREM) that binds the -180 site of the IL-2 promoter. Nuclear extracts from stimulated normal T cells display increased binding of… CONTINUE READING


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