Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphate.

@article{Lee2008MolecularBO,
  title={Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphate.},
  author={Young-Sam Lee and Kexin Huang and Florante A. Quiocho and Erin K O'Shea},
  journal={Nature chemical biology},
  year={2008},
  volume={4 1},
  pages={25-32}
}
When Saccharomyces cerevisiae cells are starved of inorganic phosphate, the Pho80-Pho85 cyclin-cyclin-dependent kinase (CDK) is inactivated by the Pho81 CDK inhibitor (CKI). The regulation of Pho80-Pho85 is distinct from previously characterized mechanisms of CDK regulation: the Pho81 CKI is constitutively associated with Pho80-Pho85, and a small-molecule ligand, inositol heptakisphosphate (IP7), is required for kinase inactivation. We investigated the molecular basis of the IP7- and Pho81… CONTINUE READING

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