Molecular basis of cryptorchidism-induced infertility

  title={Molecular basis of cryptorchidism-induced infertility},
  author={Yi-Xun Liu and Xixia Li},
  journal={Science China Life Sciences},
Artificial cryptorchidism or local testicular heat treatment can induce reversible oligospermia or azoospermia in monkeys and rats via germ cell apoptosis. Local warming of monkey testes in water at 43°C for 2 consecutive days (30 min per day) decreased the number of sperm in the semen by up to 80% on d 28, and the effect was completely reversed on d 144. Germ cells rely heavily on Sertoli cells for structural and nutritional support. Specialized junctions that play a pivotal role in… CONTINUE READING