Molecular basis of chronic lymphocytic leukemia diagnosis and prognosis

  title={Molecular basis of chronic lymphocytic leukemia diagnosis and prognosis},
  author={Mohammad Shahjahani and Javad Mohammadiasl and Fatemeh Noroozi and Mohammad Seghatoleslami and Saeid Shahrabi and Fakhredin Saba and Najmaldin Saki},
  journal={Cellular Oncology},
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in adults and is characterized by a clonal accumulation of mature apoptosis-resistant neoplastic cells. It is also a heterogeneous disease with a variable clinical outcome. Here, we present a review of currently known (epi)genetic alterations that are related to the etiology, progression and chemo-refractoriness of CLL. Relevant literature was identified through a PubMed search (1994–2014) of English-language papers using… CONTINUE READING
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