Molecular basis of basal cell carcinogenesis in the atomic-bomb survivor population: p53 and PTCH gene alterations.

@article{Mizuno2006MolecularBO,
  title={Molecular basis of basal cell carcinogenesis in the atomic-bomb survivor population: p53 and PTCH gene alterations.},
  author={Terumi Mizuno and Shoji Tokuoka and Masao Kishikawa and Eiji Nakashima and Kiyohiko Mabuchi and Keisuke S. Iwamoto},
  journal={Carcinogenesis},
  year={2006},
  volume={27 11},
  pages={2286-94}
}
Epidemiological studies suggest that UV exposure from sunlight is the major etiology for skin cancers, both melanocytic and non-melanocytic. However, the radiation-related risk for skin cancer among atomic bomb survivors of Hiroshima and Nagasaki is primarily derived from the excess risk of basal cell carcinoma (BCC), with no demonstrable excess in squamous cell carcinoma or melanoma. The BCCs in this cohort are therefore unusual in being potentially attributable to two types of radiation-UV… CONTINUE READING
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