Molecular basis of axonal dysfunction and traffic impairments in CMT.

@article{Gentil2012MolecularBO,
  title={Molecular basis of axonal dysfunction and traffic impairments in CMT.},
  author={Beno{\^i}t Jean Gentil and Laura Cooper},
  journal={Brain research bulletin},
  year={2012},
  volume={88 5},
  pages={444-53}
}
Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders. It comprises a group of diseases caused by mutations in genes involved in Schwann cells homeostasis and neuronal function that affect the peripheral nerves. So far mutations in more than 33 genes have been identified causing either the demyelinating form (CMT1) or the axonal form (CMT2). Genes involving a large variety of unrelated functions may lead to the same phenotype when mutated. Our review will… CONTINUE READING

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