Molecular basis of antigenic variation in infectious bursal disease virus.

@article{Vakharia1994MolecularBO,
  title={Molecular basis of antigenic variation in infectious bursal disease virus.},
  author={Vikram N. Vakharia and Junkun He and B B Ahamed and David B. Snyder},
  journal={Virus research},
  year={1994},
  volume={31 2},
  pages={265-73}
}
Four antigenically different strains of infectious bursal disease virus (IBDV), characterized by their reactivities with a panel of neutralizing monoclonal antibodies (MAbs), were selected to determine the molecular basis of antigenic variation. The large genome segment A, encoding the structural proteins of the U.S. variants GLS, DS326, E/Del and the vaccine strain D78, was cloned and sequenced. Comparison of the deduced amino acid sequences of the U.S. variants with other IBDV strains showed… CONTINUE READING

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