Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus.

  title={Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus.},
  author={Jonathan S. Edwards and Laurie Betts and Monica L. Frazier and Rebecca M Pollet and Stephen M. Kwong and William G. Walton and William Keith Ballentine and Julianne J Huang and Sohrab Habibi and Mark Del Campo and Jordan L Meier and Peter B. Dervan and Neville Firth and Matthew R. Redinbo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 8},
Multidrug-resistant Staphylococcus aureus infections pose a significant threat to human health. Antibiotic resistance is most commonly propagated by conjugative plasmids like pLW1043, the first vancomycin-resistant S. aureus vector identified in humans. We present the molecular basis for resistance transmission by the nicking enzyme in S. aureus (NES), which is essential for conjugative transfer. NES initiates and terminates the transfer of plasmids that variously confer resistance to a range… CONTINUE READING

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