Molecular basis of androgen insensitivity

  title={Molecular basis of androgen insensitivity},
  author={A. Brinkmann and G. Jenster and C. Ris-Stalpers and H. V. D. Korput and J. Trapman},
  • A. Brinkmann, G. Jenster, +2 authors J. Trapman
  • Published 1996
  • Biology, Medicine
  • Steroids
  • Male sexual differentiation and development proceed under direct control of androgens. Androgen action is mediated by the intracellular androgen receptor, which belongs to the superfamily of ligand-dependent transcription factors. In the X-linked androgen insensitivity syndrome, defects in the androgen receptor gene have prevented the normal development of both internal and external male structures in 46, XY individuals. The complete form of androgen insensitivity syndrome is characterized by… CONTINUE READING
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