Corpus ID: 44487462

Molecular basis of alpha-tocopherol control of smooth muscle cell proliferation.

  title={Molecular basis of alpha-tocopherol control of smooth muscle cell proliferation.},
  author={A. Azzi and E. Aratri and D. Boscoboinik and S. Cl{\'e}ment and N. Ozer and R. Ricciarelli and S. Spycher},
  volume={7 1-2},
  • A. Azzi, E. Aratri, +4 authors S. Spycher
  • Published 1998
  • Medicine
  • BioFactors
  • Rat and human vascular smooth muscle cell proliferation is specifically sensitive to alpha-tocopherol, but not beta-tocopherol. The former, but not the latter, is capable of limiting proliferation and inhibiting protein kinase C activity in a dose-dependent manner. The phenomenon occurs at concentrations in the range 10-50 microM. beta-tocopherol addition together with alpha-tocopherol, prevents both cell growth and protein kinase C inhibition. alpha-tocopherol increases de novo synthesis of… CONTINUE READING
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