Molecular basis of alpha-thalassemia in Algeria.

  title={Molecular basis of alpha-thalassemia in Algeria.},
  author={Hamida Mesbah-Amroun and Fatiha Rouabhi and Rolande Ducrocq and Jacques E Elion},
  volume={32 3},
An epidemiological molecular study was carried out to evaluate the spectrum and allelic frequency of alpha-thalassemia (alpha-thal) defects in Algeria. A series of 153 randomly selected blood donors was screened for 10 alpha-thal alleles described in the Mediterranean area. In addition, six unrelated cases with hematological and biochemical data suggestive of Hb H disease were investigated. Our data revealed an allele frequency of 4.6%. The presence of alpha(0)-thal determinants (-alpha(20.5… CONTINUE READING
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