Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications.

@article{Ouattara2013MolecularBO,
  title={Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications.},
  author={A. D. Ouattara and Shannon L Takala-Harrison and Mahamadou A Thera and D. Coulibaly and Amadou Niangaly and R{\'e}nion Saye and Youssouf Tolo and Sheetij Dutta and Donald G Heppner and Lorraine A. Soisson and Carter L. Diggs and Johan Vekemans and Joe Cohen and William C Blackwelder and Tina Dube and Matthew B Laurens and Ogobara K. Doumbo and Christopher V. Plowe},
  journal={The Journal of infectious diseases},
  year={2013},
  volume={207 3},
  pages={511-9}
}
The disappointing efficacy of blood-stage malaria vaccines may be explained in part by allele-specific immune responses that are directed against polymorphic epitopes on blood-stage antigens. FMP2.1/AS02(A), a blood-stage candidate vaccine based on apical membrane antigen 1 (AMA1) from the 3D7 strain of Plasmodium falciparum, had allele-specific efficacy against clinical malaria in a phase II trial in Malian children. We assessed the cross-protective efficacy of the malaria vaccine and inferred… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
23 Citations
27 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Similar Papers

Loading similar papers…