Molecular basis of a novel rhino (hr(rhChr)) phenotype: a nonsense mutation in the mouse hairless gene.

@article{Ahmad1998MolecularBO,
  title={Molecular basis of a novel rhino (hr(rhChr)) phenotype: a nonsense mutation in the mouse hairless gene.},
  author={Wasim Ahmad and Andrey A Panteleyev and V Henson-Apollonio and John P. Sundberg and Angela M. Christiano},
  journal={Experimental dermatology},
  year={1998},
  volume={7 5},
  pages={298-301}
}
The hairless and rhino mutations are autosomal recessive allelic mutations that map to mouse Chromosome 14. In general, the rhino phenotype is a more severe manifestation of the hairless phenotype. In both hairless and rhino mice, the hair begins shedding in a cephalocaudal pattern within 7 days after birth, and never regrows due to a series of irreversible cellular events. The hairless mutation closely resembles the human disease known as papular atrichia (MIM 209500). Recently, this disease… CONTINUE READING