Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5.

@article{Pagano2007MolecularBO,
  title={Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5.},
  author={John M. Pagano and Brian M. Farley and Lisa M. McCoig and Sean P. Ryder},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 12},
  pages={8883-94}
}
Embryonic development requires maternal proteins and RNA. In Caenorhabditis elegans, a gradient of CCCH tandem zinc finger (TZF) proteins coordinates axis polarization and germline differentiation. These proteins govern expression from maternal mRNAs by an unknown mechanism. Here we show that the TZF protein MEX-5, a primary anterior determinant, is an RNA-binding protein that recognizes linear RNA sequences with high affinity but low specificity. The minimal binding site is a tract of six or… CONTINUE READING