Molecular basis of RNA-dependent RNA polymerase II activity

@article{Lehmann2007MolecularBO,
  title={Molecular basis of RNA-dependent RNA polymerase II activity},
  author={Elisabeth Lehmann and Florian Brueckner and P. Cramer},
  journal={Nature},
  year={2007},
  volume={450},
  pages={445-449}
}
  • Elisabeth Lehmann, Florian Brueckner, P. Cramer
  • Published 2007
  • Biology, Medicine
  • Nature
  • RNA polymerase (Pol) II catalyses DNA-dependent RNA synthesis during gene transcription. There is, however, evidence that Pol II also possesses RNA-dependent RNA polymerase (RdRP) activity. Pol II can use a homopolymeric RNA template, can extend RNA by several nucleotides in the absence of DNA, and has been implicated in the replication of the RNA genomes of hepatitis delta virus (HDV) and plant viroids. Here we show the intrinsic RdRP activity of Pol II with only pure polymerase, an RNA… CONTINUE READING
    RNA polymerase II acts as an RNA‐dependent RNA polymerase to extend and destabilize a non‐coding RNA
    • 36
    • PDF
    Structure of eukaryotic RNA polymerases.
    • 263
    • PDF
    Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock.
    • 402
    • PDF
    RNAs nonspecifically inhibit RNA polymerase II by preventing binding to the DNA template.
    • 2
    • PDF
    RNA-dependent RNA polymerases in RNA silencing
    • 43

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 37 REFERENCES