Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation

Abstract

Several ion channels are thought to be directly modulated by nitric oxide (NO), but the molecular basis of this regulation is unclear. Here we show that the NMDA receptor (NMDAR)-associated ion channel was modulated not only by exogenous NO but also by endogenous NO. Site-directed mutagenesis identified a critical cysteine residue (Cys 399) on the NR2A… (More)
DOI: 10.1038/71090

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@article{Choi2000MolecularBO, title={Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation}, author={Yun-Beom Choi and Lalitha Tenneti and Dean A. Le and J. Ram{\'i}rez - Ortiz and Guang Bai and Huei-sheng Vincent Chen and Stuart A. Lipton}, journal={Nature Neuroscience}, year={2000}, volume={3}, pages={15-21} }