Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies

@inproceedings{Steinbach2013MolecularBO,
  title={Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies},
  author={Anke Steinbach and Christine Katharina Maurer and Elisabeth Weidel and Claudia Henn and Christian Brengel and Rolf W. Hartmann and Matthias Negri},
  booktitle={BMC biophysics},
  year={2013}
}
BACKGROUND PQS (PseudomonasQuinolone Signal) and its precursor HHQ are signal molecules of the P. aeruginosa quorum sensing system. They explicate their role in mammalian pathogenicity by binding to the receptor PqsR that induces virulence factor production and biofilm formation. The enzyme PqsD catalyses the biosynthesis of HHQ. RESULTS Enzyme kinetic… CONTINUE READING