Molecular basis of AKAP specificity for PKA regulatory subunits.

  title={Molecular basis of AKAP specificity for PKA regulatory subunits.},
  author={Matthew G Gold and Birgitte Lygren and Pawel Dokurno and Naoto Hoshi and George McConnachie and Kjetil Task{\'e}n and Cathrine Rein Carlson and John D Scott and David Barford},
  journal={Molecular cell},
  volume={24 3},
Localization of cyclic AMP (cAMP)-dependent protein kinase (PKA) by A kinase-anchoring proteins (AKAPs) restricts the action of this broad specificity kinase. The high-resolution crystal structures of the docking and dimerization (D/D) domain of the RIIalpha regulatory subunit of PKA both in the apo state and in complex with the high-affinity anchoring peptide AKAP-IS explain the molecular basis for AKAP-regulatory subunit recognition. AKAP-IS folds into an amphipathic alpha helix that engages… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 47 references

Designing isoform-specific peptide disruptors of protein kinase A localization.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 5 Excerpts
Highly Influenced

Likelihood-enhanced fast translation functions.

Acta crystallographica. Section D, Biological crystallography • 2005
View 1 Excerpt

Role of A kinase anchor proteins in the tissue - specific regulation of lipoprotein lipase

C. Rosenmund, D. W. Carr, +3 authors G. L. Westbrook
Mol . Endocrinol . • 2005
View 1 Excerpt

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