Molecular basis for the tissue specificity of β-catenin oncogenesis

  title={Molecular basis for the tissue specificity of β-catenin oncogenesis},
  author={Alpana Sharma and Jyoti Misra Sen},
Wnt-β-catenin-T-cell factor signaling is causally linked to c-myc-dependent tumorigenesis in mouse and human colon epithelial cells. By contrast, β-catenin is not similarly associated with oncogenic transformation of other tissues, including T cells. The molecular basis for tissue specificity of β-catenin-dependent oncogenesis is unknown. Here, we demonstrate that adenomatous polyposis coli mutant APCMin/+ mice, which have increased expression of β-catenin in all tissues, develop severe… CONTINUE READING

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