Molecular basis for the management of secondary hyperparathyroidism in chronic renal failure.

@article{Fukagawa1995MolecularBF,
  title={Molecular basis for the management of secondary hyperparathyroidism in chronic renal failure.},
  author={Masafumi Fukagawa and Hui Yi and Naoko Fukuda and Kiyoshi Kurokawa},
  journal={Artificial organs},
  year={1995},
  volume={19 12},
  pages={1210-4}
}
Recent clinical and experimental data suggest that the resistance of parathyroid cells to the physiological concentration of calcitriol plays an important role in the pathogenesis and the progression of secondary hyperparathyroidism in chronic renal failure. This resistance is due to the decreased density of the calcitriol receptor in parathyroid cells, which may result from impaired upregulation of calcitriol receptor. Since patients with larger parathyroid glands were more resistance to… CONTINUE READING