Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7.

@article{Lee2003MolecularBF,
  title={Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7.},
  author={Jongdae Lee and Tsung-Hsien Chuang and Vanessa Redecke and Liping She and P. M. Pitha and Dennis Anthony Carson and Eyal Raz and Howard B Cottam},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 11},
  pages={6646-51}
}
Certain C8-substituted and N7, C8-disubstituted guanine ribonucleosides comprise a class of small molecules with immunostimulatory activity. In a variety of animal models, these agents stimulate both humoral and cellular immune responses. The antiviral actions of these guanosine analogs have been attributed to their ability to induce type I IFNs. However, the molecular mechanisms by which the guanosine analogs potentiate immune responses are not known. Here, we report that several guanosine… CONTINUE READING
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