Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia

@inproceedings{Bassi2012MolecularBF,
  title={Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia},
  author={Sarah Cristina Bassi and Eduardo M Rego},
  booktitle={Revista brasileira de hematologia e hemoterapia},
  year={2012}
}
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid receptor alpha rearrangement. This rearrangement interacts with several proteins, including the native promyelocytic leukemia gene, thus causing its delocalization from the nuclear bodies, impairing its function. The immunofluorescence staining… CONTINUE READING