Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis.
@article{Nishikimi1991MolecularBF, title={Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis.}, author={M. Nishikimi and K. Yagi}, journal={The American journal of clinical nutrition}, year={1991}, volume={54 6 Suppl}, pages={ 1203S-1208S } }
The inability of humans to synthesize L-ascorbic acid is known to be due to a lack of L-gulono-gamma-lactone oxidase, an enzyme that is required for the biosynthesis of this vitamin. [...] Key Result Sequence analysis study indicated that the human L-gulono-gamma-lactone oxidase gene has accumulated a large number of mutations since it stopped being active and that it now exists as a pseudogene in the human genome.Expand Abstract
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