Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis.

  title={Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis.},
  author={Morimitsu Nishikimi and Kunio Yagi},
  journal={The American journal of clinical nutrition},
  volume={54 6 Suppl},
  • M. NishikimiK. Yagi
  • Published 1 December 1991
  • Biology, Computer Science
  • The American journal of clinical nutrition
The inability of humans to synthesize L-ascorbic acid is known to be due to a lack of L-gulono-gamma-lactone oxidase, an enzyme that is required for the biosynthesis of this vitamin. [] Key Result Sequence analysis study indicated that the human L-gulono-gamma-lactone oxidase gene has accumulated a large number of mutations since it stopped being active and that it now exists as a pseudogene in the human genome.

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Missing Step in Man, Monkey and Guinea Pig required for the Biosynthesis of L-Ascorbic Acid

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