Molecular basis for the actions of Hsp90 inhibitors and cancer therapy

@article{Yamaki2011MolecularBF,
  title={Molecular basis for the actions of Hsp90 inhibitors and cancer therapy},
  author={Hiroshi Yamaki and Motowo Nakajima and Kumiko Watanabe Shimotohno and Nobuo Tanaka},
  journal={The Journal of Antibiotics},
  year={2011},
  volume={64},
  pages={635-644}
}
Heat-shock protein 90 (Hsp90) inhibitor downregulates c-Myc expression and upregulates the expression of tumor repressor proteins such as p53 and pRB, inhibiting the G1/S transition and causing G2/M arrest during cell cycle progression. The cycle progression is extensively controlled by the pRB/E2F signaling pathway. E2F is released from the pRB/E2F complex with the phosphorylation of pRB by cyclin–cyclin-dependent kinase (CDK) complexes. The released E2F promotes the transcription of target… CONTINUE READING
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