Molecular basis for several drug-induced nephropathies.

  title={Molecular basis for several drug-induced nephropathies.},
  author={Jerry R. Mitchell and R J McMurtry and C N Statham and Sidney D. Nelson},
  journal={The American journal of medicine},
  volume={62 4},
A recent clinical advance has been the discovery that many drug-induced hepatic diseases result from the metabolic activation of chemically stable drugs to potent alkylating agents by the liver. In addition to the liver, however, the kidney also contains active enzyme systems capable of metabolically activating drugs and other chemicals. For this reason a… CONTINUE READING