Molecular basis for mustard-induced vesication.

  title={Molecular basis for mustard-induced vesication.},
  author={Bruno Papirmeister and Clark L. Gross and Henry Louis Meier and John P. Petrali and John Bertrand Johnson},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={5 6 Pt 2},
A biochemical hypothesis explaining the generation of pathology in human skin by mustard gas (HD) is presented which links the initiation of DNA damages to local alterations of metabolism and subsequent development of blisters. The proposed sequence involves HD alkylation of purines in DNA which are processed to form apurinic sites. Apurinic endonucleases act at these sites to produce backbone breaks in DNA which cause activation of the chromosomal enzyme poly(ADP-ribose)polymerase. This enzyme… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 55 extracted citations

Similar Papers

Loading similar papers…