Molecular basis for multimerization in the activation of the epidermal growth factor receptor


The epidermal growth factor receptor (EGFR) is activated by dimerization, but activation also generates higher-order multimers, whose nature and function are poorly understood. We have characterized ligand-induced dimerization and multimerization of EGFR using single-molecule analysis, and show that multimerization can be blocked by mutations in a specific… (More)
DOI: 10.7554/eLife.14107


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