Molecular basis for glucocorticoid induction of the Kruppel-like factor 9 gene in hippocampal neurons.

@article{Bagamasbad2012MolecularBF,
  title={Molecular basis for glucocorticoid induction of the Kruppel-like factor 9 gene in hippocampal neurons.},
  author={Pia D. Bagamasbad and Tim Ziera and Steffen A Borden and Ronald M Bonett and Aaron M. Rozeboom and Audrey F. Seasholtz and Robert J Denver},
  journal={Endocrinology},
  year={2012},
  volume={153 11},
  pages={5334-45}
}
Stress has complex effects on hippocampal structure and function, which consequently affects learning and memory. These effects are mediated in part by circulating glucocorticoids (GC) acting via the intracellular GC receptor (GR) and mineralocorticoid receptor (MR). Here, we investigated GC regulation of Krüppel-like factor 9 (KLF9), a transcription factor implicated in neuronal development and plasticity. Injection of corticosterone (CORT) in postnatal d 6 and 30 mice increased Klf9 mRNA and… CONTINUE READING
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