Molecular basis for gene-specific transactivation by nuclear receptors.

  title={Molecular basis for gene-specific transactivation by nuclear receptors.},
  author={Mads Malik Aagaard and Rasmus Siersb{\ae}k and S Mandrup},
  journal={Biochimica et biophysica acta},
  volume={1812 8},
Nuclear receptors (NRs) are key transcriptional regulators of metazoan physiology and metabolism. Different NRs bind to similar or even identical core response elements; however, they regulate transcription in a highly receptor- and gene-specific manner. These differences in gene activation can most likely be accounted for by mechanisms involving receptor-specific interactions with DNA as well as receptor-specific interactions with protein complexes binding to adjacent and distant DNA sequences… CONTINUE READING