Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide.

@article{Arenz2014MolecularBF,
  title={Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide.},
  author={Stefan Arenz and Haripriya Ramu and Pulkit Gupta and Otto Berninghausen and Roland Beckmann and Nora V{\'a}zquez-Laslop and Alexander S Mankin and Daniel N. Wilson},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={3501}
}
In bacteria, ribosome stalling during translation of ErmBL leader peptide occurs in the presence of the antibiotic erythromycin and leads to induction of expression of the downstream macrolide resistance methyltransferase ErmB. The lack of structures of drug-dependent stalled ribosome complexes (SRCs) has limited our mechanistic understanding of this regulatory process. Here we present a cryo-electron microscopy structure of the erythromycin-dependent ErmBL-SRC. The structure reveals that the… CONTINUE READING
20 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

cis-acting modulators of translation

  • K. Ito, Chiba, S. Arrest peptides
  • Annu. Rev. Biochem. 82, 171–202
  • 2013

Structural basis for TetM-mediated tetracycline resistance

  • A Dönhöfer
  • Proc. Natl Acad. Sci. USA 109,
  • 2012

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea

  • T Becker
  • Nature 482,
  • 2012

species-specific binding and action

  • K. Kannan, Mankin, A. S. Macrolide antibiotics in the ribosome exit tunnel
  • Ann. NY Acad. Sci 1241, 33–47
  • 2012

Similar Papers

Loading similar papers…