Molecular basis for chemoprevention by sulforaphane: a comprehensive review

@article{Juge2007MolecularBF,
  title={Molecular basis for chemoprevention by sulforaphane: a comprehensive review},
  author={Narinobu Juge and Richard F. Mithen and Maria Traka},
  journal={Cellular and Molecular Life Sciences},
  year={2007},
  volume={64},
  pages={1105-1127}
}
The consumption of cruciferous vegetables has long been associated with a reduced risk in the occurrence of cancer at various sites, including the prostate, lung, breast and colon. This protective effect is attributed to isothiocyanates present in these vegetables, and sulforaphane (SF), present in broccoli, is by far the most extensively studied to uncover the mechanisms behind this chemoprotection. The major mechanism by which SF protects cells was traditionally thought to be through Nrf2… CONTINUE READING
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