Molecular basis for cell tropism of CXCR4-dependent human immunodeficiency virus type 1 isolates.

@article{Tokunaga2001MolecularBF,
  title={Molecular basis for cell tropism of CXCR4-dependent human immunodeficiency virus type 1 isolates.},
  author={Kenzo Tokunaga and Michael L. Greenberg and Michael Andew Morse and Rob I. Cumming and H Kim Lyerly and Bryan R Cullen},
  journal={Journal of virology},
  year={2001},
  volume={75 15},
  pages={6776-85}
}
Laboratory isolates of human immunodeficiency virus type 1 (HIV-1) that utilize CXCR4 as a coreceptor infect primary human macrophages inefficiently even though these express a low but detectable level of cell surface CXCR4. In contrast, infection of primary macrophages by primary CXCR4-tropic HIV-1 isolates is readily detectable. Here, we provide evidence suggesting that this difference in cell tropism results from a higher requirement for cell surface CXCR4 for infection by laboratory HIV-1… CONTINUE READING

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