Molecular basis for Rac2 regulation of phagocyte NADPH oxidase

  title={Molecular basis for Rac2 regulation of phagocyte NADPH oxidase},
  author={Becky A. Diebold and Gary M. Bokoch},
  journal={Nature Immunology},
A Rac GTPase–regulated multiprotein NADPH oxidase is critical for the formation of reactive oxygen species (ROS) in phagocytic leukocytes and other nonphagocytic cells. NADPH oxidase reduces molecular oxygen to form superoxide anion in a two-step process. Electrons are initially transferred from NADPH to cytochrome b–associated FAD, then to cytochrome b heme and finally to molecular oxygen. We show here that Rac is required for both electron-transfer reactions. Mutational and biophysical… CONTINUE READING
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Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

  • Roberts, A.W
  • Immunity 10,
  • 1999

J.The p67phox activation domain regulates electron flow from NADPH to flavin in flavocytochrome b558

  • Y. Nisimoto, S. Motalebi, Han, C.-H, Lambeth
  • J. Biol
  • 1999

an update

  • Babior, B. M. NADPH oxidase
  • Blood 93, 1464–1476
  • 1999

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