Molecular basis and clinical application of biological markers of bone turnover.

@article{Calvo1996MolecularBA,
  title={Molecular basis and clinical application of biological markers of bone turnover.},
  author={Mona S. Calvo and David R Eyre and Caren M. Gundberg},
  journal={Endocrine reviews},
  year={1996},
  volume={17 4},
  pages={333-68}
}
An ideal battery of tests would include indices of bone resorption and formation. They should be unique to bone, reflect total skeletal activity, and should correlate with traditional measures of bone remodeling activity, such as radiocalcium kinetics, histomorphometry, or changes in bone mass. Factors that confound their measurement, such as circadian rhythms, diet, age, sex, bone mass, liver function, and kidney clearance rates, should be clearly defined (Fig. 9). To date, no bone marker has… CONTINUE READING