Molecular background of leak K+ currents: two-pore domain potassium channels.

  title={Molecular background of leak K+ currents: two-pore domain potassium channels.},
  author={P. Enyedi and G. Czirj{\'a}k},
  journal={Physiological reviews},
  volume={90 2},
  • P. Enyedi, G. Czirják
  • Published 2010
  • Medicine, Chemistry
  • Physiological reviews
  • Two-pore domain K(+) (K(2P)) channels give rise to leak (also called background) K(+) currents. The well-known role of background K(+) currents is to stabilize the negative resting membrane potential and counterbalance depolarization. However, it has become apparent in the past decade (during the detailed examination of the cloned and corresponding native K(2P) channel types) that this primary hyperpolarizing action is not performed passively. The K(2P) channels are regulated by a wide variety… CONTINUE READING
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