Molecular assessment of the role of envelope-associated structural proteins in cross neutralization among different PRRS viruses

Abstract

To assess the role of each envelope-associated protein (i.e., ORFs 2–6 products) of type 2 PRRSV in cross neutralization mediated by antibody, chimeric mutants were generated by replacing ORFs of a VR2332-based infectious clone with those of JA142, SDSU73, PRRS124, or 2M11715 that are genetically and antigenically distinct from VR2332 and two-way… (More)
DOI: 10.1007/s11262-008-0278-1

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