Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism.

@article{Degiacomi2013MolecularAO,
  title={Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism.},
  author={Matteo T. Degiacomi and Ioan Iacovache and Lucile Pernot and Mohamed Chami and Misha Kudryashev and Henning Stahlberg and F Gisou van der Goot and Matteo dal Peraro},
  journal={Nature chemical biology},
  year={2013},
  volume={9 10},
  pages={623-9}
}
Aerolysin is the founding member of a superfamily of β-pore-forming toxins whose pore structure is unknown. We have combined X-ray crystallography, cryo-EM, molecular dynamics and computational modeling to determine the structures of aerolysin mutants in their monomeric and heptameric forms, trapped at various stages of the pore formation process. A dynamic modeling approach based on swarm intelligence was applied, whereby the intrinsic flexibility of aerolysin extracted from new X-ray… CONTINUE READING
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