Molecular assays in the diagnosis of neonatal sepsis: a systematic review and meta-analysis.

@article{Pammi2011MolecularAI,
  title={Molecular assays in the diagnosis of neonatal sepsis: a systematic review and meta-analysis.},
  author={Mohan Pammi and Angela R. B. Flores and Mariska Leeflang and James Versalovic},
  journal={Pediatrics},
  year={2011},
  volume={128 4},
  pages={e973-85}
}
BACKGROUND Microbial cultures for diagnosis of neonatal sepsis suffer from low sensitivity and reporting delay. Advances in molecular microbiology have fostered new molecular assays that are rapid and may improve neonatal outcomes. OBJECTIVES We assessed whether molecular assays have sufficient sensitivity (>0.98) and specificity (>0.95) to replace microbial cultures in the diagnosis of neonatal sepsis and explored heterogeneity by use of subgroup analyses based on the type of assay… CONTINUE READING
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