Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients.

@article{Iwamoto2008MolecularAO,
  title={Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients.},
  author={Takuji Iwamoto and Hiroshi Okamoto and Yoshiaki Toyama and Shigeki Momohara},
  journal={The FEBS journal},
  year={2008},
  volume={275 18},
  pages={4448-55}
}
Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. The inflammatory process is characterized by infiltration of inflammatory cells into the joints, leading to proliferation of synoviocytes and destruction of cartilage and bone. In RA synovial tissue, the infiltrating cells such as macrophages, T cells, B cells and dendritic cells play important role in the pathogenesis of RA. Migration of leukocytes into… CONTINUE READING
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