• DOI:10.1038/nrm2310
Corpus ID: 34121605

Molecular architecture of the kinetochore–microtubule interface

@article{Cheeseman2008MolecularAO,
  title={Molecular architecture of the kinetochore–microtubule interface},
  author={I. Cheeseman and A. Desai},
  journal={Nature Reviews Molecular Cell Biology},
  year={2008},
  volume={9},
  pages={33-46}
}

• I. Cheeseman, A. Desai
• Published 2008
• Biology, Medicine
• Nature Reviews Molecular Cell Biology

Segregation of the replicated genome during cell division in eukaryotes requires the kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed of a number of conserved protein complexes that direct its specification and assembly, bind to spindle microtubules and regulate chromosome segregation. Recent studies have identified more than 80 kinetochore components, and are revealing how these proteins are organized into the higher order kinetochore structure, as well… Expand

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