Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker.

@article{Chandler2009MolecularAO,
  title={Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker.},
  author={Natalie J. Chandler and Ian D. Greener and James O. Tellez and Shin Inada and Hanny Musa and Peter Molenaar and Dario DiFrancesco and Mirko Baruscotti and Renato Longhi and Robert H. Anderson and Rudolf Billeter and Vinod Sharma and Daniel C. Sigg and Mark R. Boyett and Halina Dobrzynski},
  journal={Circulation},
  year={2009},
  volume={119 12},
  pages={1562-75}
}
BACKGROUND Although we know much about the molecular makeup of the sinus node (SN) in small mammals, little is known about it in humans. The aims of the present study were to investigate the expression of ion channels in the human SN and to use the data to predict electrical activity. METHODS AND RESULTS Quantitative polymerase chain reaction, in situ hybridization, and immunofluorescence were used to analyze 6 human tissue samples. Messenger RNA (mRNA) for 120 ion channels (and some related… CONTINUE READING
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