Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.

  title={Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.},
  author={Vadim K Pedchenko and Olga Grigorievna Bondar and Agnes B. Fogo and Roberto Vanacore and Paul A. Voziyan and Arthur Richard Kitching and J{\"o}rgen Wieslander and Clifford E. Kashtan and D B Borza and Eric G. Neilson and Curtis B. Wilson and Billy G Hudson},
  journal={The New England journal of medicine},
  volume={363 4},
BACKGROUND In Goodpasture's disease, circulating autoantibodies bind to the noncollagenous-1 (NC1) domain of type IV collagen in the glomerular basement membrane (GBM). The specificity and molecular architecture of epitopes of tissue-bound autoantibodies are unknown. Alport's post-transplantation nephritis, which is mediated by alloantibodies against the GBM, occurs after kidney transplantation in some patients with Alport's syndrome. We compared the conformations of the antibody epitopes in… CONTINUE READING
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