Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.

  title={Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.},
  author={Mukta Ullah and Nadine Pelletier and Lin Xiao and Song Xian Zhao and Kainan Wang and Cindy Degerny and Soroush Tahmasebi and Christelle Cayrou and Yannick Doyon and Siew-Lee Goh and Nathalie Champagne and Jacques C{\^o}t{\'e} and X M Yang},
  journal={Molecular and cellular biology},
  volume={28 22},
The monocytic leukemia zinc finger protein MOZ and the related factor MORF form tetrameric complexes with ING5 (inhibitor of growth 5), EAF6 (Esa1-associated factor 6 ortholog), and the bromodomain-PHD finger protein BRPF1, -2, or -3. To gain new insights into the structure, function, and regulation of these complexes, we reconstituted them and performed various molecular analyses. We found that BRPF proteins bridge the association of MOZ and MORF with ING5 and EAF6. An N-terminal region of… CONTINUE READING
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