Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography

@article{Sui2006MolecularAO,
  title={Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography},
  author={Haixin Sui and Kenneth H Downing},
  journal={Nature},
  year={2006},
  volume={442},
  pages={475-478}
}
The axoneme, which forms the core of eukaryotic flagella and cilia, is one of the largest macromolecular machines, with a structure that is largely conserved from protists to mammals. Microtubule doublets are structural components of axonemes that contain a number of proteins besides tubulin, and are usually found in arrays of nine doublets arranged around two singlet microtubules. Coordinated sliding of adjacent doublets, which involves a host of other proteins in the axoneme, produces… CONTINUE READING
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