Molecular archaeology of the Escherichia coli genome.

  title={Molecular archaeology of the Escherichia coli genome.},
  author={Jeffrey G. Lawrence and Howard Ochman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 16},
The availability of the complete sequence of Escherichia coli strain MG1655 provides the first opportunity to assess the overall impact of horizontal genetic transfer on the evolution of bacterial genomes. We found that 755 of 4,288 ORFs (547.8 kb) have been introduced into the E. coli genome in at least 234 lateral transfer events since this species diverged from the Salmonella lineage 100 million years (Myr) ago. The average age of introduced genes was 14.4 Myr, yielding a rate of transfer 16… CONTINUE READING
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Lawrence et al

  • J. Mecsas, Strauss, 2 E.J.Emerg.Inf.Dis., 271–288. Evolution
  • Proc. Natl. Acad. Sci. USA 95
  • 1998

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