Molecular approaches to treatment of hepatocellular carcinoma.

  title={Molecular approaches to treatment of hepatocellular carcinoma.},
  author={Anja Lachenmayer and Clara Alsinet and Charissa Y. Chang and Josep M Llovet},
  journal={Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver},
  volume={42 Suppl 3},
Hepatocellular carcinoma (HCC) remains a highly complex disease resistant to commonly used chemotherapy and radiotherapy. As the sixth most common cancer worldwide with the third highest mortality rate and very poorly understood molecular pathways driving hepatocarcinogenesis, new treatment strategies are urgently needed for this devastating disease. The multikinase inhibitor sorafenib was the first molecular targeted drug in HCC that led to significant survival benefit in patients with… CONTINUE READING

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