Molecular and therapeutic characterization of anti-ectodysplasin A receptor (EDAR) agonist monoclonal antibodies.

@article{Kowalczyk2011MolecularAT,
  title={Molecular and therapeutic characterization of anti-ectodysplasin A receptor (EDAR) agonist monoclonal antibodies.},
  author={Christine Kowalczyk and Nathalie Dunkel and Laure Willen and Mercedes Casal and Elizabeth A. Mauldin and Olivier Gaide and Aubry Tardivel and Giovanna Badic and A Etter and Manuel Favre and Douglas M. Jefferson and Denis J Headon and St{\'e}phane Demotz and Pascal Schneider},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 35},
  pages={30769-79}
}
The TNF family ligand ectodysplasin A (EDA) and its receptor EDAR are required for proper development of skin appendages such as hair, teeth, and eccrine sweat glands. Loss of function mutations in the Eda gene cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a condition that can be ameliorated in mice and dogs by timely administration of recombinant EDA. In this study, several agonist anti-EDAR monoclonal antibodies were generated that cross-react with the extracellular domains of… CONTINUE READING
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Agonist Anti-EDAR Antibodies 30778 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • E. A. Mauldin, O. Gaide, P. Schneider, M. L. Casal
  • Am. J. Med. Genet. A 149A,
  • 2009
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